Brain - Gut Connection/ Health/ Inflammation/ Leaky Gut/ Mineral Depletion/ Nutritional Medicine

The Brain – Gut Connection

The Brain -Gut Connection

Brain Fog – ADHD – Autism – Dementia – Alzheimer’s – Anxiety – Depression – Multiple Sclerosis – Eating Disorders

Obsessive Compulsive Disorder – IBS – Tourettes – Schizophrenia

The Brain – Gut Connection is being talked about throughout the Medical and Nutritional world. What goes on in the gut directly affects our mood, cognitive ability and brain function. We have known about this connection for years but mistakenly thought the communication was only one way – as when anxiety can cause nausea and diarrhoea and depression can cause changes in appetite but not the other way round. Now we know that the communications between the trillions of bacteria living in our gut and the enormous amount of neurons surrounding it are in constant two-way contact with the Brain and many are now calling the gut our second Brain. It also goes some way to explaining why we say we have ‘gut feelings’ and ‘trust your gut’! A multitude of conditions as listed above are now thought to have a connection to problems of inflammation and gut dysfunction due to the wrong mix of good bacteria or infection with toxic ones.

What are the causes of gut dysfunction and inflammation?

  • Gut wall integrity is vital to good health. The gut wall is only one cell thick and has the surface area of a tennis court. Many problems can cause this area to become inflamed and leaky – meaning that the product of our digestion and bacteria which should be contained within our digestive tract can enter the bloodstream.
  • Chronic constipation.
  • Stress
  • Environmental Toxins
  • High blood sugar – when the blood sugar is kept high due to a poor diet of sugar and carbohydrates, sugar binds to protein in a process called ‘glycation‘ and high glycation leads to actual shrinkage of the brain as well as release of high levels of inflammatory chemicals called ‘cytokines‘ and increased leakiness of the gut lining.
  • Antibiotics -either given to us or to animals that we eat can damage our good bacteria in what is referred to as our Microbiome.
  • Lack of B Vitamins -that frequently follows antibiotic use.
  • Gastroenteritis and chronic infections with overgrowth of toxic bacteria like Clostridium Dificile and similar, difficult to treat infections.
  • High levels of Omega 6 fats in the body that fuel inflammation.
  • Exposure to gliadin, a protein in gluten containing foods, increases permeability to the blood/brain barrier and gluten increases leaky gut.
  • The gut is lined with gram negative bacteria (LPS) and if these enter the systemic circulation it triggers widespread inflammation including in the brain.
  • When we get inflammation and pain the anti-inflammatory drugs given may relieve some of the symptoms but the condition will actually worsen because the drugs also irritate the digestive tract. Frequently these anti-inflammatories are given with stomach acid lowering drugs which upsets our digestion and assimilation of nutrients from our food and also the balance of bacteria in the digestive tract.
  • Histamine Intolerance – caused by too little of the enzyme DAO (diamine oxidase) that breaks down Histamine in foods. Too much Histamine causes leaky gut and a damaged gut can’t then make more of the enzyme. Magnesium is also necessary to make DAO therefore low levels of this mineral also affect the gut. For more information click Allergy

When the Brain gets inflammatory Cytokines it responds by sending messages to the Adrenal glands to produce Cortisol which can lead to more gut leakiness, further changes in gut bacteria  and more inflammation that affects the brain. The only way to stop the cycle is to heal the gut. See the Posts on Leaky Gut and Healing Your Digestive tract.

Beneficial bacteria in the gut have another purpose – they manufacture neurotransmitters that affect our sleep cycles, and activities in the brain and Central nervous System. Inflammation in the gut disrupts the Tryptophan – 5HTP – Serotonin – Melatonin pathways which can lead to sleep problems, anxiety, depression and other mental problems as too much Tryptophan that is not converted to 5HTP will be converted into a brain irritant called quinolinate. If there is any balance or movement disorder then it can be GABA that is affected.


  1. An Elimination Diet for 2- 4 weeks is preferable. This is discussed in more detail in previous posts but essentially means eliminating all Dairy products, grains and processed foods plus eating plenty of green vegetables, berries, quality meats and fish plus healthy fats such as olive oil, coconut oil, avocado. This diet will probably identify any problem foods and will also kick-start the body into burning fat instead of Carbohydrates. This is called a ketogenic diet and it can improve mental function quite dramatically.
  2. Probiotics to repopulate the gut with beneficial bacteria. I use Optibacs and they even do one for infants. It is important to vary the mix of bacteria every few weeks. If there are bowel symptoms I also use a special Probiotic called Saccharomyces Boulardii that can remove yeasts and bacteria – even Clostridium Difficile. If there is anxiety then Lactobacillus rhamnosus has been shown to lower levels of anxiety, decrease stress hormones and even increase brain receptors for Serotonin. There is a strain of Bifido bacteria that secretes large amounts of GABA. In ADHD low GABA is often the problem – not a Ritalin deficiency. In Autism levels of Clostridium histolyticum can be high and producing too much propionic acid that can be toxic.
  3. Prebiotics fuel for the beneficial bacteria, such as onions, garlic, chives, leeks, broccoli.
  4. Vitamins B complex including B6 and B12 ( from wild salmon, organic liver, organic beef, lamb and free range eggs.)and Vitamin D3 and a good level of plant minerals as they are essential for the action of over 300 enzymes, especially Magnesium will help. Epson salt baths are an easy way to get more magnesium into the body.
  5. L-Glutamine either powder or capsules can help the gut lining to heal.
  6. Digestive Enzymes can be very helpful. For more info. Enzyme Stuff
  7. Omega 3 oils – fish oils, Krill oil are very anti-inflammatory and also help brain function.
  8. Avoid sugar, alcohol and artificial sweeteners (Aspartame is more damaging to the gut flora than sugar)

This is all quite new but much more money is now going into research because Autism alone has increased more than 100% in one decade, Dementia and Alzheimers are epidemic. Scientists still aren’t sure exactly what makes up a healthy microbiome and they are not yet clear on whether certain bacterial strains are vital to mental functioning or whether the right balance is what is most important but we do know that we are seeing marked improvement when we focus on diet and gut health. Some Doctors have been using faecal transplants from health family members and getting good results, some advocate putting probiotics into enemas and administering them straight into the area they are needed. One Doctor reported quite amazing improvement in her husband with advanced Alzheimer’s, when giving him 2 Tblsps of Coconut oil a day and she monitored his progress by asking him to draw a clock face.

The good thing is that we don’t have to wait 20 years for clinical trials – these treatments are safe and actionable now. Start a food and mood diary and don’t get discouraged by set backs. If you give the body what it needs it will frequently be able to heal itself.

More links Autism Speaks and Autism Research Institute and  David Perlmutter MD and Gluten free foods

                                  David Perlmutter has also written several books – his latest being Brain Maker

 and also the already famous Grain Brain


2 thoughts on “The Brain – Gut Connection

  1. I’ve been a fan of omega 3 for ages. I believe in what it can do to help maintain a health body and mind. I typically supplement my diet with fish oil soft gels that have about 180mg EPA and 120mg DHA.

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